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228,229,230 Inhibiting xCT The search for strategies and drugs aimed at inducing oxidative stress has revealed xCT to be a suitable target—increased glutamate efflux through this antiporter is an important process for cells to generate sufficient glutathione to cope with high intracellular ROS levels

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Figure 2: Effects of oral GSH supplementation on levels of GSH in plasma, lymphocytes, and buccal cells after 1 month, 3 months, 6 months, and 7 months of treatment